The Red Wings fell to 0-2 in the preseason following a 6-5 overtime loss to the Penguins in Pittsburgh last night.
Gustav Nyquist scored twice, while Darren Helm, Ben Street and Matt Lorito each had a goal for Detroit.
Goalie Jimmy Howard stopped 22 of the 25 shots he faced and netminder Tom McCollum turned aside nine shots on goal.
The Wings continue exhibition play as they face off against the Blackhawks in Chicago tonight before hosting the Boston Bruins in the first game at Little Caesars Arena Saturday.