The Lions' five-game winning streak ended with a 17-6 loss to the Giants at New York. Matthew Stafford threw for 273 yards and an interception, playing with a special glove to protect his injured finger.
Odell Beckham Junior's one-yard touchdown catch iced the cake at MetLife Stadium. Beckham also had a punt-return touchdown that was called back due to a penalty.
Eli Manning threw for 201 yards and two scores for New York, which has won eight of its past nine games.
Matthew Stafford threw for 273 yards and an interception as Detroit's offense was held to just two field goals. The 9-and-5 Lions still lead the NFC North by one game over Green Bay.
The Lions play at Dallas next Monday.