The Lions are 2-and-0 after a 24-10 win over the Giants on "Monday Night Football" in New Jersey.
Matthew Stafford threw a pair of first-half touchdown passes and Jamal Agnew returned a punt 88 yards for a TD early in the fourth quarter for Detroit.
Ameer Abdullah had 86 yards on the ground.
The Lions are 2-and-0 for the first time since 2011.
Eli Manning passed for 239 yards, a touchdown and an interception for New York.
The Lions host Atlanta this Sunday.