Max Kepler hit a two-run homer and Logan Morrison added a solo shot and drove in three as Minnesota downed the Blue Jays 8-3 in the opener of a three-game series.
Eduardo Escobar drove in a pair for the Twins (45-53), and Joe Mauer was 3 for 5 with an RBI.
Adalberto Mejia (1-0) allowed one run and eight hits over 5 1/3 innings while striking out three and walking two.
Lourdes Gurriel Jr. was 2 for 4 with a homer for the Blue Jays (46-53), extending his multi-hit streak to six games.
Luis Santos (0-1) pitched two innings in his first major league start as the Jays opted for a bullpen day in the absence of Marco Estrada (left glute strain).
Toronto used six relievers over nine innings.
Ryan Borucki takes another crack at getting his elusive first win in the majors tonight.
The 24-year-old left-hander has gone 0-and-1 in four starts with the Jays.